Effect of Knee Position on Muscle Loss During Leg Immobilization

This study looks at what happens to leg muscles when the knee is kept straight or bent during five days of wearing a brace. We want to find out if keeping the knee bent (so the thigh muscle is stretched) helps prevent muscle loss compared to keeping the knee straight. Thirty healthy adults will take part. They will wear a knee brace for five days and have several tests before and after, including scans, blood samples, and small muscle samples. The results may help doctors find better ways to protect muscles when people cannot move, for example after surgery or illness.

NCT Number	NCT07690150
Lead Sponsor	Wageningen University Collaborators: ZonMw: The Netherlands Organisation for Health Research and Development
Conditions	Muscle Atrophy, Disuse Atrophy, Immobilization
Enrollment	30 participants
Start Date	2026-08-01
Primary Completion	2028-03-01 (estimated)
Study Completion	2028-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-08