Ozone Versus Conventional Socket Disinfection for Primary Dental Implant Stability

This randomized split-mouth controlled clinical trial aims to compare the effects of ozone and conventional implant site disinfection on primary and early secondary implant stability. Systemically healthy adults requiring at least two dental implants in symmetrical or contralateral edentulous sites will receive ozone disinfection at one implant site and conventional disinfection at the paired site according to a randomized allocation. Implant stability will be assessed immediately after implant placement using insertion torque and resonance frequency analysis (Implant Stability Quotient, ISQ), and secondary stability will be evaluated by ISQ measurements at the 3-month follow-up during healing abutment placement. The study will determine whether ozone disinfection improves implant stability during the early osseointegration period.

NCT Number	NCT07687680
Lead Sponsor	Zeliha Başak Çakır Erdil
Conditions	Dental Implant Placement, Ozone Therapy
Enrollment	51 participants
Start Date	2025-11-18
Primary Completion	2026-07-20 (estimated)
Study Completion	2026-07-20 (estimated)
Updated on ClinicalTrials.gov	2026-07-20