Dietary Fiber to Induce Gut Microbiota-mediated Response to Immunotherapy in Melanoma.

Previous research has shown that a higher fiber intake may have a beneficial effect on the intestinal health and improve the effectiveness of immunotherapy, but this is not certain. The objective of this double-blinded randomized clinical trial is to analyze, whether increased dietary fiber intake by patients with metastatic melanoma will increase the relative amount of Bifidobacterium, which in turn stimulates immune cell activity and improves the response to immunotherapy.

NCT Number	NCT07686835
Lead Sponsor	Radboud University Medical Center Collaborators: Wageningen University and Research
Conditions	Melanoma (Skin) Stage IV, Melanoma (Skin Cancer), Melanoma Metastatic, Melanoma Advanced, Melanoma
Enrollment	70 participants
Start Date	2026-07-31
Primary Completion	2028-05-01 (estimated)
Study Completion	2029-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-27