Abuse Liability of Four Modern Oral Nicotine Products

This is a single-site, open-label, randomized, 6-way crossover study designed to evaluate elements of abuse liability (AL) including subjective effects, physiological measures (pharmacodynamics \[PD\]), and plasma nicotine uptake (pharmacokinetics \[PK\]) during controlled monitored use and following ad libitum use of the study investigational products (IPs) by generally healthy smokers who are also users of smokeless tobacco.

NCT Number	NCT07685795
Lead Sponsor	RAI Services Company
Conditions	Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Enrollment	50 participants
Start Date	2026-07-15
Primary Completion	2026-09-15 (estimated)
Study Completion	2027-01-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-06