Clinical Trial

Imaging and Predictive Modelling of Proliferative Vitreoretinopathy.

Enrolling by Invitation
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Summary
Patients with retinal detachment are at risk of recurrence and failure of surgery requiring multiple surgeries due to a condition called proliferative vitreoretinopathy (PVR). Study aims to help tailor patients' treatments and improve outcomes by: \[i\] studying imaging biomarkers of PVR, and \[ii\] develop AI models for PVR detection. Inclusion: * Patients with 'complicated' retinal detachment with PVR recruited to a phase 1 dose-finding trial called MORPH-1. * Patients with 'simple' retinal detachment without PVR recruited to a PhD study. Non -invasive multimodal imaging and anonymized imaging will be used to study imaging biomarkers of PVR and develop deep learning models to predict PVR in collaboration with an artificial intelligence (AI) expert team at UCL Institute of Ophthalmology.
Trial Details
NCT Number NCT07682025
Lead Sponsor University College, London
Conditions Proliferative Vitreoretinopathy
Enrollment 100 participants
Start Date 2026-10-12
Primary Completion 2027-10-15 (estimated)
Study Completion 2027-10-15 (estimated)
Updated on ClinicalTrials.gov 2026-07-02