IL-6 and Cortisol Responses to Cycling Exercise

This study aimed to investigate salivary interleukin-6 (IL-6) and cortisol responses following short-term and long-term cycling exercise in team athletes with different cardiorespiratory fitness levels. Participants completed a Wingate anaerobic cycling test and a YMCA submaximal cycling test in a randomized crossover design separated by a seven-day washout period. Saliva samples were collected before exercise, immediately after exercise, and 30 minutes after exercise to determine IL-6 and cortisol concentrations. The study also examined whether cardiorespiratory fitness level influenced the magnitude of these physiological responses.

NCT Number	NCT07681362
Lead Sponsor	Ondokuz Mayıs University
Conditions	Exercise Physiology, Cardiorespiratory Fitness, Interleukin-6, Cortisol
Enrollment	27 participants
Start Date	2025-05-05
Primary Completion	2025-06-05 (estimated)
Study Completion	2025-06-05 (estimated)
Updated on ClinicalTrials.gov	2026-07-06