The goal of this observational study is to learn about the long-term effects of anthracycline chemotherapy on inflammation, oxidative stress, and heart function in adult women with breast cancer.
The main questions it aims to answer are:
1. Do inflammatory cytokine levels change after anthracycline chemotherapy and remain altered many years after treatment?
2. Are long-term markers of oxidative stress and antioxidant capacity associated with changes in heart structure or function after anthracycline exposure?
This study does not include a comparison group. All participants were previously treated with anthracycline-based chemotherapy as part of their standard cancer care.
Participants will:
1. Provide blood samples for the measurement of inflammatory cytokines and oxidative stress-related biomarkers
2. Undergo a clinical cardiovascular evaluation
3. Receive a transthoracic echocardiogram to assess heart function, including measures of systolic and diastolic function and myocardial deformation
4. Participate in a long-term follow-up assessment approximately 10 years after their initial cancer treatment