Clinical Trial

TENS of Auricular Vagal Nerve for Radiation Necrosis

Not Yet Recruiting
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Summary
This is a multi-center, randomized, blinded trial evaluating the effect of transcutaneous auricular vagal nerve stimulator (taVNS) on radiation necrosis-related cerebral edema. In this study, consenting and eligible patients will be assigned to one of two arms: treatment (Arm 1) or sham (Arm 2). Patients in both arms will have imaging performed and tissue and blood collected for assessment of changes in area of contrast enhancement and cerebral edema, inflammatory markers, and markers of blood-brain barrier permeability.
Trial Details
NCT Number NCT07680127
Lead Sponsor Virginia Commonwealth University
Conditions Radiation Necrosis, Cerebral Edema
Enrollment 40 participants
Start Date 2026-07-31
Primary Completion 2029-08-31 (estimated)
Study Completion 2029-08-31 (estimated)
Updated on ClinicalTrials.gov 2026-07-02