RESISTANCE TRAINING AND CAPILLARIZATION - ROLE ON THE ANABOLIC RESPONSE IN OLDER ADULTS

The goal of this clinical trial is to learn how muscle capillaries influence the response to resistance exercise training in older adults. The study will include older men and women who may experience age-related declines in muscle mass and function. The main questions it aims to answer are: * Does baseline muscle capillarization influence the increase in muscle size and function following resistance exercise training? * Can resistance exercise stimulate the formation of new capillaries in older adults with lower baseline capillarization, and how is this related to muscle growth? Participants will: * Undergo assessments of muscle structure, capillarization, and physical function before and after the intervention. * Participate in a supervised resistance exercise training program. * Provide muscle samples and other physiological measurements to evaluate changes in muscle growth and blood vessel formation. Researchers will analyze the relationship between baseline muscle capillarization, exercise-induced angiogenesis, and improvements in muscle mass and function to better understand why some older adults respond more effectively to resistance exercise than others.

NCT Number	NCT07680036
Lead Sponsor	University of Padova
Conditions	Older Adults (65 Years and Older)
Enrollment	30 participants
Start Date	2024-01-01
Primary Completion	2025-12-31 (estimated)
Study Completion	2026-05-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-07