Modeling the Early Stages of Autoimmunity Through the Study of Immunological Thrombocytopenic Purpura and Juvenile Lupus

Immunologic thrombocytopenic purpura (ITP) in children is a pre-lupus condition if associated with the presence of anti-nuclear antibodies (ANA), providing a unique model for understanding the natural history of autoimmunity, particularly that of systemic lupus erythematosus (SLE). The investigators will describe the shared and/or unique immunological pathways involved at diagnosis in 70 children with ITP and in 20 children with SLE, and compare them between ITP-ANA- (more often transient), ITP-ANA+ (pre-lupus condition, more often persistent) and SLE

NCT Number	NCT07680010
Lead Sponsor	University Hospital, Bordeaux
Conditions	Immune Thrombocytopenic Purpura ( ITP ), Systemic Lupus Erythematosus (SLE)
Enrollment	105 participants
Start Date	2026-07
Primary Completion	2029-10 (estimated)
Study Completion	2033-10 (estimated)
Updated on ClinicalTrials.gov	2026-07-17