Clinical Trial

Pupillary Light Reflex to Predict Post-Spinal Hypotension in Elective Cesarean Delivery

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Summary
This prospective observational cohort study investigates whether pre-anesthetic pupillary light reflex (PLR) parameters can predict the risk of hypotension following spinal anesthesia in women undergoing elective cesarean section. Spinal anesthesia-induced hypotension is common, with reported incidence rates of 50-90%, and current predictors such as baseline blood pressure and BMI have limited accuracy. PLR, a sensitive marker of autonomic nervous system balance, may offer a simple, objective, and non-invasive tool for identifying patients at higher risk. The study evaluates pupillary reaction latency and other PLR parameters and correlates them with post-spinal blood pressure changes to determine their predictive value.
Trial Details
NCT Number NCT07678723
Lead Sponsor Al-Azhar University
Conditions Hypotension, Spinal Anesthesia, Cesarean Delivery
Enrollment 200 participants
Start Date 2026-06-28
Primary Completion 2026-09-30 (estimated)
Study Completion 2026-10-31 (estimated)
Updated on ClinicalTrials.gov 2026-07-01