Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT07676435 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Ongoing Lung Decline With Age Intensified Response

Study acronym: OLD AIR
StatusRecruiting
PhasePhase 2
Started2026-06-17
View on ClinicalTrials.gov ↗

Amendment history

2026-06-30
Study Status, Study Design, Eligibility, Contacts/Locations v1
Recruitment opened
Study sites0→1
Eligibility criteria-6 characters
Inclusion Criteria: - Adults aged 60 years and older who are physically capable of participating in study procedures; willing Willing to be randomized to fisetin or placebo; weight stable within the previous 2 months (<5-pound change); no No blood donation within 2 months before screening; absence of unstable chronic disease; willing Willing to maintain baseline activity level throughout the study; body Body mass index <30 kg/m²; and either Either a history of at least 10 pack-years of cigarette smoking or [...]
2026-06-24
Original filing
This Phase II, randomized, double-blind, placebo-controlled pilot study will evaluate the effects of fisetin, a senolytic flavonoid compound, on lung function and biomarkers of cellular senescence in older adults aged 60 years and older. Participants will include individuals with a history of at least 10 pack-years of smoking as well as age-matched never-smokers. Forty participants will be randomized to receive either fisetin or placebo using a short-course "hit-and-run" dosing strategy (approximately 20 mg/kg/day orally for 2 consecutive days on Days 1-2 and Days 8-9).
Trial Details
NCT Number NCT07676435
Lead Sponsor Cedars-Sinai Medical Center
Conditions Age-Related Lung Function Decline
Enrollment 40 participants
Start Date 2026-06-17
Primary Completion 2027-06-16 (estimated)
Study Completion 2027-07-15 (estimated)
Updated on ClinicalTrials.gov 2026-07-01