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INterest of the Negative Predictive Value of Integrons in the reduCtion of Large Broad-spectrum anTibiotics Consumption for Urinary Tract infectionS

Study acronym: INVICTUS
StatusNot Yet Recruiting
PhaseNot applicable
Started2026-09-15
View on ClinicalTrials.gov ↗

Amendment history

2026-06-29
Study Identification, Study Status, Study Description v1
Study description-37 characters
WeThe promotor conducted a multicenter prospective study, IRIS (Interest o [...] gh negative predictive value (NPV) for antibiotic resistance (Barraud O et al. J Antimicrob Chemother 2021). Among the 343 patients admitted in the ED or intensive care [...]
Study title-20 characters
[...] pectrum anTibiotics Consumption for Urinary Tract infectionS: a Randomized Trial
2026-06-23
Original filing
Urinary tract infections (UTI), mainly driven by Gram-negative bacteria (GNB) are a frequent cause of hospitalization and the second cause of antibiotic prescription after lower respiratory tract infections. Integrons play a major role in the dissemination of antibiotic resistance among GNB. In the prospective INVICTUS project, whose ultimate objective is to reduce the use of large broad-spectrum antibiotics, our hypothesis is that, in adult patients with a non-severe UTI (qSOFA\<2) and a former documentation with a 3GC-resistant GNB in the previous 6 months, integrons search could reduce the empirical use of large broad-spectrum antibiotics.
Trial Details
NCT Number NCT07675018
Lead Sponsor University Hospital, Limoges
Conditions Drug Resistance, Microbial, Biomarkers, Urinary Tract Infections (UTI's), Antibacterial Agents
Enrollment 204 participants
Start Date 2026-09-15
Primary Completion 2028-09-21 (estimated)
Study Completion 2028-09-21 (estimated)
Updated on ClinicalTrials.gov 2026-07-01