Clinical Trial

An Investigation of Topical Ophthalmic Low-Dose Atropine on Pupil Size and Accommodation

Completed Phase 1
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Summary
The goal of this clinical study is to learn about the short-term physiological effects of low-dose atropine in healthy volunteers. The study seeks to examine three questions related to low-dose topically applied ophthalmic atropine: 1. Does applying two drops of 0.01% atropine sulfate solution cause the same clinical effects as one drop of 0.02% atropine? 2. How quickly do the pupil responses and accommodative amplitudes recover following a dose of 0.01% atropine, 0.02% atropine, and 0.05% atropine? 3. Does applying a single drop of 0.02% atropine sulfate solution cause the same clinical effects in participants with light vs. dark iris colors? Participants will have their pupil size and accommodative status measured at appropriate intervals to answer the questions above.
Trial Details
NCT Number NCT07674966
Lead Sponsor University of California, Berkeley
Conditions Myopia
Enrollment 24 participants
Start Date 2022-03-16
Primary Completion 2022-10-09 (estimated)
Study Completion 2022-10-09 (estimated)
Updated on ClinicalTrials.gov 2026-06-30