Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain

The purpose of this superiority randomized controlled trial is to evaluate the effect of daily knee sleeve use on 5-year radiographic knee osteoarthritis progression and knee-related symptoms in older adults with chronic knee pain. The investigators will recruit 235 individuals aged 50-64 years at baseline with chronic (≥ 3 months) knee pain, randomized to daily use of an elasticized fabric knee sleeve versus no knee sleeve use. Participants will have knee radiographs at baseline and year 5 and will complete a survey including Knee injury and Osteoarthritis Outcome Score (KOOS) subscales for pain, knee function and quality of life at 3 months and annually. A prespecified interim analysis of the 1-year KOOS subscore data will be performed.

NCT Number	NCT07674901
Lead Sponsor	Margaret L Gourlay, MD, MPH Collaborators: Knee Sleeve Trial Collaborative, LLC
Conditions	Knee Arthritis, Osteoarthritis
Enrollment	235 participants
Start Date	2026-09
Primary Completion	2032-09 (estimated)
Study Completion	2032-09 (estimated)
Updated on ClinicalTrials.gov	2026-07-01