Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD

Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies. This randomized pilot trial tests whether a single session of acute intermittent hypercapnic hypoxia (AIHH) or hypercapnic normoxia (AIHN) improves upper airway and axial motor function in Parkinsonism, and explores biomarker correlates of intervention responsiveness.

NCT Number	NCT07674264
Lead Sponsor	University of Florida
Conditions	Parkinson Disease, Parkinsonism
Enrollment	32 participants
Start Date	2026-06-20
Primary Completion	2028-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-29