Clinical Trial

Outlining Biological Effects of Subthalamic Deep Brain Stimulation in Parkinson's Disease Patients.

Study acronym: BRAIN-DBS-GAIN
Not Yet Recruiting
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Summary
The aim of the study is to characterize the neuroinflammatory effects of subthalamic deep brain stimulation in patients with Parkinson's disease, by analyzing changes in blood neuroinflammatory and neurodegenerative biomarkers before and after surgery (at 6 and 12 months, respectively), and comparing the changes in blood biomarkers levels with a control group of patients with advanced PD on best medical treatment.
Trial Details
NCT Number NCT07673783
Lead Sponsor Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Collaborators: Ministry of Health, Italy, Azienda Ospedaliero-Universitaria di Modena, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Conditions Parkinson Disease (PD)
Enrollment 90 participants
Start Date 2026-09-01
Primary Completion 2028-02-29 (estimated)
Study Completion 2028-02-29 (estimated)
Updated on ClinicalTrials.gov 2026-06-29