Efficacy and Safety of Oral Antiviral Therapy for Idiopathic Trigeminal Neuralgia

This is a multicenter, prospective, randomized, controlled trial. A total of 165 patients with idiopathic trigeminal neuralgia will be enrolled and randomly divided into three groups at a 1:1:1 ratio. The aim is to compare the efficacy and safety of conventional carbamazepine monotherapy, carbamazepine combined with oral antiviral therapy, and carbamazepine combined with anti-inflammatory therapy in pain relief, quality of life improvement and adverse event profiles.

NCT Number	NCT07673549
Lead Sponsor	Beijing Tiantan Hospital Collaborators: Beijing Sanbo Brain Hospital
Conditions	Idiopathic Trigeminal Neuralgia
Enrollment	165 participants
Start Date	2026-08-31
Primary Completion	2027-12-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-29