Extracellular Vesicles for Rejection Monitoring in Cardiac Transplantation

This study will analyze extracellular vesicle (EV)-derived protein profiles in heart transplantated patients during the first 15 months post-transplantation to investigate, if there are distinct EV-derived proteins or protein patterns that allow early and reliable diagnosis of acute cardiac allograft rejection. Additionally, it will explore temporal changes in the EV-derived protein profile during the early postoperative period irrespective of acute allograft rejection, and will investigate, if there are correlations between EV protein markers and imaging findings.

NCT Number	NCT07673536
Lead Sponsor	Laurenz Kopp Fernandes
Conditions	Rejection Heart Transplant
Enrollment	30 participants
Start Date	2026-06-18
Primary Completion	2028-09-30 (estimated)
Study Completion	2028-11-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-01