Clinical Trial

Can Vitamin D Replacement Correct Chronic Disease Anemia?

Completed Phase 4
View on ClinicalTrials.gov →
Summary
This prospective, single-arm interventional pilot study evaluated whether vitamin D supplementation alone improves iron status in adults with inflammatory bowel disease (IBD) who are in clinical remission and have concurrent vitamin D deficiency. Because vitamin D can suppress hepcidin-a key regulator that inhibits iron absorption-the investigators hypothesized that correcting vitamin D deficiency might improve iron parameters. Adult IBD patients (Crohn's disease or ulcerative colitis) in clinical remission with serum 25-hydroxyvitamin D \<20 ng/mL, ferritin \<40 µg/L, and no anemia received oral cholecalciferol (50,000 IU weekly for 8 weeks, followed by 2,000 IU daily) and were reassessed at 3 months. The primary outcome was the within-subject change in iron parameters (serum iron, ferritin, and transferrin saturation) from baseline to 3 months. The study also examined the change in 25(OH)D and explored differences by IBD subtype and biologic therapy use.
Trial Details
NCT Number NCT07673497
Lead Sponsor Gazi University
Conditions Vitamin D, Iron Deficiency and Overload, Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
Enrollment 43 participants
Start Date 2022-09-30
Primary Completion 2023-03-30 (estimated)
Study Completion 2023-05-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-29