Clinical Trial

Intensive vs. Standard Blood Pressure Control in Primary Aldosteronism

Study acronym: Intensia-Aldo
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Summary
The goal of this clinical trial is to evaluate whether an intensive blood pressure control strategy (systolic blood pressure target \<120 mmHg) is more effective than a standard strategy (systolic blood pressure target \<140 mmHg) in reducing the risk of cardiovascular events in patients with primary aldosteronism. The main question it aims to answer is: Does the intensive blood pressure control strategy reduce the risk of composite cardiovascular events more than the standard strategy in patients with primary aldosteronism? The study employs a randomized design, allocating participants in a 1:1 ratio to either the Intensive Treatment Group or the Standard Treatment Group. Researchers will compare the differences in cardiovascular outcomes and safety profiles between the two groups over a planned follow-up period of 6 to 10 years. Participants will: Undergo randomization and adhere to the assigned blood pressure management protocol. Attend regular follow-up visits for blood pressure measurement, laboratory tests, questionnaires, etc. Report any adverse events or changes in health status.
Trial Details
NCT Number NCT07673445
Lead Sponsor Chongqing Medical University
Collaborators: First Affiliated Hospital of Chongqing Medical University
Conditions Primary Aldosteronism
Enrollment 3,830 participants
Start Date 2026-06
Primary Completion 2036-12 (estimated)
Study Completion 2036-12 (estimated)
Updated on ClinicalTrials.gov 2026-06-29