Ultrasound-Guided Hook-Wire Localization for Excision of Non-palpable Cervical Lesions Suspicious for Metastasis

The goal of this randomized controlled trial is to determine whether ultrasound-guided hook-wire localization improves surgical efficiency and accuracy compared with ultrasound-guided surgery alone for the excision of non-palpable or difficult-to-palpate cervical lesions suspicious for metastatic disease in adult patients. The main questions it aims to answer are: * Does ultrasound-guided hook-wire localization reduce operative time compared with ultrasound-guided excision alone? * Does hook-wire localization improve surgical precision, including successful retrieval of the target lesion for histopathological assessment? * Does hook-wire localization affect incision length, procedural difficulty, or the risk of surgical complications? Researchers will compare patients undergoing ultrasound-guided hook-wire localization followed by surgical excision with patients undergoing ultrasound-guided excision alone to determine whether hook-wire guidance improves surgical outcomes. Participants will: * Undergo ultrasound-guided localization and surgical excision of a cervical lesion or lymph node suspicious for malignancy. * Be randomly assigned to either: ultrasound-guided hook-wire localization before surgery, or ultrasound-guided excision without hook-wire localization. * Have surgical outcomes assessed, including operative time, incision length, successful lesion retrieval, procedural difficulty, and intraoperative or postoperative complications.

NCT Number	NCT07672912
Lead Sponsor	Rusana Bark
Conditions	Non Palpable Cervical Lesions Suspicious for Metastasis
Enrollment	50 participants
Start Date	2021-04-15
Primary Completion	2025-11-21 (estimated)
Study Completion	2026-06-09 (estimated)
Updated on ClinicalTrials.gov	2026-07-07