Small RNA tRF-31 Changes in Patients With Age-Related Cataract

The goal of this observational study is to evaluate the expression characteristics and clinical relevance of the tRF-31/HIPK2 signaling axis in adults over 18 years old with age-related cataract (ARC). The main questions it aims to answer are: Is there a correlation between the relative expression levels of tRF-31 and its target gene HIPK2 in the anterior lens capsule and the clinical severity (Emery-Little grading system) of age-related cataracts? Does oxidative stress in the anterior segment microenvironment have a potential bystander effect on the state of the corneal endothelium? Participants will:Undergo routine preoperative ophthalmologic examinations, including visual acuity tests, slit-lamp photography, and corneal endothelial cell counting. Undergo standard cataract surgery (phacoemulsification combined with intraocular lens implantation) as part of their regular medical care. Allow researchers to collect and analyze their anterior lens capsule tissue, which is routinely removed and typically discarded as medical waste during the standard continuous curvilinear capsulorhexis (CCC) step of the surgery.

NCT Number	NCT07672899
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions	Cataract
Enrollment	200 participants
Start Date	2026-06-17
Primary Completion	2026-08-16 (estimated)
Study Completion	2026-09-16 (estimated)
Updated on ClinicalTrials.gov	2026-06-29