Tranexamic Acid to Reduce Blood Loss After Varus Derotation Osteotomy

TABLO (Tranexamic Acid to reduce Blood Loss after varus derotation Osteotomy) is a clinical trial of postoperative tranexamic acid vs placebo in non-ambulatory children with cerebral palsy (CP) undergoing reconstructive hip surgery. Improving surgical outcomes is a high priority in this patient population given the high risk of bleeding and the diminished capacity for these children to withstand substantial blood loss. Preliminary data from the study institution indicates that approximately one third of these patients receive transfusion of blood products in the postoperative period. There is growing evidence that hidden blood loss occurring in the postoperative period is substantial and can potentially be attenuated with the administration of Tranexamic Acid (TXA). However, trials on postoperative TXA have been carried out exclusively in adult surgical populations.

NCT Number	NCT07672158
Lead Sponsor	Murdoch Childrens Research Institute Collaborators: University of Melbourne, Royal Children's Hospital
Conditions	Cerebral Palsy, Hip Surgery Corrective, Tranexamic Acid Use, Blood Loss, Surgical, Paediatrics, Orthopedics
Enrollment	52 participants
Start Date	2026-07
Primary Completion	2028-08 (estimated)
Study Completion	2029-04 (estimated)
Updated on ClinicalTrials.gov	2026-06-26