Bone Substitutes and NIPSA in Intrabony Periodontal Defects: A Randomized Controlled Trial

This multicenter randomized controlled clinical trial aims to compare the clinical, radiographic, microbiological and molecular outcomes of two collagenated xenogeneic bone substitutes (GTO® and GenOs®) used in combination with the Non-Incised Papilla Surgical Approach (NIPSA) for the treatment of intrabony periodontal defects. The study will evaluate whether differences exist between the two biomaterials with respect to clinical attachment gain, defect resolution, wound healing and biological markers of regeneration.

NCT Number	NCT07671963
Lead Sponsor	University of Belgrade Collaborators: Cittadella Universitaria
Conditions	Periodontitis (Stage 3), Minimally Invasive Surgical Procedures, Bone Substitutes
Enrollment	30 participants
Start Date	2026-07-01
Primary Completion	2027-02-01 (estimated)
Study Completion	2027-03-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-26