* The goal of study is to evaluate the effectiveness of adipose tissue derived-MSCs concentrate application in mandibular fractures. The main question it aims to answer is: Does intervention enhance bone quality, reduce complications and reduce bone regeneration time.
* Researchers will compare the effectiveness of adipose tissue derived-MSCs concentrate application with ORIF to ORIF alone to see if MSCs improve healing in mandibular fractures.
* Participants will:
* Be managed either by adipose tissue derived-MSCs concentrate application with ORIF or ORIF alone.
* Undergo CBCT immediately (T1) and 3 months (T4) postoperatively for bone density radiographic evaluation
* Visit the clinic postoperatively at one week (T2), one month (T3), three months (T4) for clinical examination
Protocol Amendment History
1 amendment
This ClinicalTrials.gov record has been amended once since 2026-06-22.