Clinical Trial

GoFast CAR T-Cell Therapy for Recurrent Refractory B-Cell Lymphoma

Not Yet Recruiting Early Phase 1
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Summary
This is an investigator-initiated, prospective, open-label exploratory clinical study designed to evaluate the safety and preliminary efficacy of GoFast CD19 CAR T-cell therapy in adult patients with recurrent or refractory B-cell lymphoma. Eligible patients will undergo screening, baseline assessment, peripheral blood or leukapheresis collection, lymphodepleting chemotherapy, and intravenous infusion of GoFast CD19 CAR T cells. The study plans to enroll 9 participants using a sequential dose-escalation design. The primary outcome is objective response rate, and secondary outcomes include complete remission rate, overall survival, progression-related survival outcomes, duration of response, MRD negativity, and adverse events.
Trial Details
NCT Number NCT07670260
Lead Sponsor Chinese PLA General Hospital
Conditions Relapsed or Refractory Large B-cell Lymphoma
Enrollment 9 participants
Start Date 2026-06-30
Primary Completion 2027-09-30 (estimated)
Study Completion 2028-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-26