Preoperative Ankle-Brachial Index and Renal Adverse Events After Acute Type A Aortic Dissection Surgery

This retrospective cohort study will evaluate whether a high preoperative ankle-brachial index is associated with postoperative renal adverse events in patients with acute Stanford type A aortic dissection who underwent surgical repair. The ankle-brachial index is a noninvasive vascular measurement that may reflect arterial stiffness and vascular calcification. A high ankle-brachial index may indicate abnormal vascular aging and impaired vascular compliance. The study will use existing clinical data from patients treated at Nanjing First Hospital, Nanjing Medical University, between January 2021 and February 2024. No intervention will be assigned as part of this study. The primary aim is to examine the association between a preoperative ankle-brachial index of 1.4 or higher and the risk of acute kidney injury within 7 days after surgery.

NCT Number	NCT07668830
Lead Sponsor	Nanjing First Hospital, Nanjing Medical University
Conditions	Aortic Dissection Type A, Acute Kidney Injury Cardiac Surgery
Enrollment	516 participants
Start Date	2021-01-01
Primary Completion	2024-02-29 (estimated)
Study Completion	2024-02-29 (estimated)
Updated on ClinicalTrials.gov	2026-06-29