Clinical Trial

Peri-implant Soft Tissue Augmentation Using Microneedling With i-PRF vs. Connective Tissue Graft

Not Yet Recruiting
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Summary
This randomized controlled clinical trial aims to evaluate a minimally invasive technique for peri-implant soft tissue augmentation using microneedling combined with injectable platelet-rich fibrin (i-PRF) compared with the current gold-standard connective tissue graft (CTG). Patients with thin peri-implant soft tissue requiring implant second-stage surgery in the esthetic zone will be randomly assigned to receive either CTG harvested from the palate or a series of microneedling and i-PRF treatments. Clinical outcomes including mucosal thickness, keratinized tissue width, peri-implant health parameters, volumetric soft tissue changes, esthetic outcomes, and patient-reported measures of pain and satisfaction will be evaluated during follow-up. The study aims to determine whether microneedling with i-PRF can provide comparable soft tissue augmentation while reducing patient morbidity associated with connective tissue graft harvesting.
Trial Details
NCT Number NCT07667855
Lead Sponsor Beirut Arab University
Conditions Thin Peri-implant Mucosal Phenotype
Enrollment 24 participants
Start Date 2026-06-26
Primary Completion 2027-02-26 (estimated)
Study Completion 2027-03-26 (estimated)
Updated on ClinicalTrials.gov 2026-06-25