This study aims to evaluate the effects of a role-playing method in epilepsy teaching on nurse-patient communication skills, self-efficacy, and knowledge among undergraduate nursing students in Hainan Province, China. Participants will be undergraduate nursing students who meet the eligibility criteria. They will be assigned to either an intervention group or a control group. The intervention group will receive epilepsy teaching using the role-playing method, while the control group will receive conventional teaching. The outcomes will include nurse-patient communication skills, self-efficacy, and epilepsy-related knowledge. The findings of this study may provide evidence for improving nursing education methods and enhancing undergraduate nursing students' learning outcomes.