Antimicrobial Efficacy of NaOCl and PDT in Primary Root Canal Treatment

This clinical study will compare different root canal disinfection methods used during primary root canal treatment. Root canal infection is mainly caused by bacteria inside the root canal system. Sodium hypochlorite is commonly used as a root canal irrigant because it helps reduce bacteria. Photodynamic therapy is an additional disinfection method that uses a photosensitizing solution and light activation to help kill bacteria. Participants who need primary root canal treatment will be randomly assigned to one of the study groups. The study will compare sodium hypochlorite irrigation alone with sodium hypochlorite supplemented with photodynamic therapy. Additional comparison groups will be used to assess the antimicrobial effect of the disinfection procedures. Bacterial samples will be collected from the root canals before and after the assigned disinfection protocol to measure the reduction in bacterial counts. The main outcome of the study is the reduction in intracanal bacterial load after the disinfection procedure. Postoperative pain will also be assessed using a visual analogue scale at selected time points after treatment. All participants will receive standard root canal treatment, and the final clinical disinfection and treatment procedures will be completed according to accepted endodontic practice.

NCT Number	NCT07666932
Lead Sponsor	Bayan Alqrenawi
Conditions	Dental Pulp Necrosis, Apical Periodontitis
Enrollment	64 participants
Start Date	2025-05-19
Primary Completion	2026-04-20 (estimated)
Study Completion	2026-04-20 (estimated)
Updated on ClinicalTrials.gov	2026-07-01