Safety and Efficacy of Renal Denervation for Untreated Grade I Hypertension: a Pilot Study

Prospective, Multi-Center, Randomized, shame-Controlled, Uptake clinical trial to evaluate the efficacy and safety of the six-channel radio-frequency（RF) renal denervation system-comprising the six-channel RF generator (specification model: 25D1G, software release version: SRG-V1) and the disposable ultra-guiding RF denervation catheter (specification model: 25C6W127F115T)-for renal denervation in patients with grade I hypertension and without taking antihypertensive medicines.

NCT Number	NCT07664787
Lead Sponsor	Ruijin Hospital Collaborators: Guangdong Provincial People's Hospital, Shanghai Tongji Hospital, Tongji University School of Medicine, Shandong First Medical University, Shanghai Institute of Hypertension, Shanghai Golden Leaf MedTec Co. Ltd
Conditions	Hypertension, Grade 1
Enrollment	20 participants
Start Date	2026-07-01
Primary Completion	2027-12-30 (estimated)
Study Completion	2027-12-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-24