Clinical Trial

Effects of Stimulant Medications in PTSD

Study acronym: SMP
Not Yet Recruiting Phase 1
View on ClinicalTrials.gov →
Summary
While there have been advances in understanding post-traumatic stress disorder (PTSD) as a disorder and its biological features, unfortunately only one out of five traumatized persons with PTSD reach remission after cycling through evidence-based and/or FDA-approved medications. This is especially unfortunate given that people with PTSD are often from vulnerable populations, or those whose professions entail personal sacrifice. It is clear that new serotonergic antidepressants and atypical antipsychotics will not be sufficient to fix this gap, and new mechanisms of action need to be tested. In the current proposal, the investigators test the hypothesis that mixed amphetamine salts (brand name Adderall), FDA-approved for treating attention deficit hyperactivity disorder (ADHD), can improve PTSD outcomes.
Trial Details
NCT Number NCT07664631
Lead Sponsor University of Chicago
Collaborators: Cures Within Reach
Conditions Adderall, PTSD, Post Traumatic Stress Disorder
Enrollment 40 participants
Start Date 2026-09-15
Primary Completion 2027-09-15 (estimated)
Study Completion 2027-09-15 (estimated)
Updated on ClinicalTrials.gov 2026-06-24