Clinical Trial

Remimazolam-Flumazenil Versus Sevoflurane for Hysteroscopic Day Surgery

Not Yet Recruiting Phase 4
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Summary
This prospective, single-center, randomized controlled trial aims to compare remimazolam anesthesia with planned flumazenil reversal and sevoflurane-based balanced anesthesia in adult women undergoing ambulatory hysteroscopic surgery. Participants will be randomly assigned in a 1:1 ratio to receive either remimazolam for induction and maintenance followed by flumazenil reversal or propofol induction followed by sevoflurane-based balanced anesthesia. The primary outcome is anesthesia-controlled time, defined as the sum of induction time and emergence time. Secondary outcomes include recovery profiles, postoperative symptoms, quality of recovery, hemodynamic stability, and the incidence of re-sedation. The study will evaluate whether a remimazolam-flumazenil strategy can improve operating room efficiency while maintaining recovery quality and safety comparable to conventional sevoflurane-based anesthesia in the ambulatory surgery setting.
Trial Details
NCT Number NCT07663877
Lead Sponsor Chung-Ang University Gwangmyeong Hospital
Conditions Hysteroscopy, Ambulatory Surgery, General Anesthesia
Enrollment 124 participants
Start Date 2026-06
Primary Completion 2028-06 (estimated)
Study Completion 2028-06 (estimated)
Updated on ClinicalTrials.gov 2026-06-23