Clinical Trial

Mycophenolate Mofetil w/ Prednisone for Immune Related Hepatitis From Checkpoint Inhibitor Therapy

Not Yet Recruiting Phase 2
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Summary
This phase II study evaluates whether early treatment with mycophenolate mofetil (MMF) plus prednisone improves liver inflammation caused by immune checkpoint inhibitors. The study includes patients who develop moderate to severe immune-related hepatitis after receiving PD-(L)1 or CTLA-4-based cancer therapy. The main goal is to determine how many patients experience improvement in liver function within 30 days while successfully tapering steroids. Safety and treatment-related side effects will also be monitored.
Trial Details
NCT Number NCT07663422
Lead Sponsor Fox Chase Cancer Center
Conditions Immune-mediated Hepatitis, Immune-related Adverse Event
Enrollment 31 participants
Start Date 2026-06-30
Primary Completion 2028-03-31 (estimated)
Study Completion 2028-09-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-23