Controlled Hypotension and Renal Injury During Septoplasty

This prospective randomized single-blind study investigated the effects of two different mean arterial pressure (MAP) targets during controlled hypotension on renal injury in patients undergoing septoplasty. Participants were randomized to a low MAP target group (50-57 mmHg) or a higher MAP target group (58-65 mmHg). Renal injury was assessed using plasma neutrophil gelatinase-associated lipocalin (NGAL) levels measured at baseline, 6 hours, and 24 hours postoperatively.

NCT Number	NCT07662577
Lead Sponsor	Fatih Sultan Mehmet Training and Research Hospital
Conditions	Hypotension During Surgery, NGAL, Kidney Injury
Enrollment	110 participants
Start Date	2019-05-01
Primary Completion	2020-05-01 (estimated)
Study Completion	2020-08-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-23