Clinical Trial

Clinical Evaluation of Platelet Rich Fibrin Membrane With or Without Hyaluronic Acid Along With Coronally Advanced Flap in the Treatment of Rt1 Gingival Recession

Active, Not Recruiting
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Record status
This record was last updated June 23, 2026 (before its estimated July 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
Gingival recession is a common mucogingival deformity that may result in root hypersensitivity, esthetic concern, plaque accumulation, and difficulty in oral hygiene maintenance. Modified coronally advanced flap procedures are widely used for Cairo RT1 gingival recession defects. Platelet-rich fibrin has been used as an autologous biologic adjunct, while hyaluronic acid has shown potential benefits in wound hydration, inflammation modulation, and soft tissue healing. Aim: To evaluate the clinical effectiveness of multilayered platelet-rich fibrin with cross-linked hyaluronic acid compared with platelet-rich fibrin alone in the treatment of Cairo RT1 gingival recession defects using modified coronally advanced flap without vertical releasing incisions.
Trial Details
NCT Number NCT07662447
Lead Sponsor Gulf Medical University
Conditions PRF, Gingival Recession, Hyaluronic Acid
Enrollment 30 participants
Start Date 2025-07-01
Primary Completion 2026-07-01 (estimated)
Study Completion 2026-09-10 (estimated)
Updated on ClinicalTrials.gov 2026-06-23