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Salivary Biomarkers in Periodontal Disease Progression

Study acronym: PERIO-BIO
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated June 22, 2026 (before its estimated July 10, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Study First Submitted
This study aims to evaluate salivary biomarkers associated with bone remodeling during the transition from periodontal health to disease. Periodontal diseases are characterized by chronic inflammation that can lead to connective tissue destruction and alveolar bone loss. Although diagnosis is primarily based on clinical and radiographic findings, these methods may not fully reflect disease activity or progression. In this observational study, individuals with periodontal health, gingivitis, and periodontitis will be included. Salivary levels of IL-17, IL-23, IL-6, TGF-β, RANKL, and OPG will be measured using ELISA. The relationship between these biomarkers and periodontal disease stage and grade will be analyzed. The results are expected to improve understanding of the biological mechanisms underlying periodontal disease progression and to assess the potential role of salivary biomarkers in early diagnosis and personalized treatment approaches.
Trial Details
NCT Number NCT07661784
Lead Sponsor Suleyman Demirel University
Conditions
(from sponsor)		 Periodontal Disease, Gingivitis and Periodontal Diseases, Periodontitis
Related terms Camurati-Engelmann Syndrome, Gingivitis, Periodontal Diseases, Periodontitis
Enrollment 240 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov