Cannabis and Opioid Use Disorder, Study 2

This inpatient study enrolls healthy individuals who have opioid use disorder. Participants live at the University of Kentucky Hospital for approx. 6 weeks. During this time, we will examine how repeated doses of oral cannabis and acute doses of oral and inhaled cannabis 1) modify the intensity and time course of opioid withdrawal, 2) modify the effects of intranasal opioid administration and 3) impact the safety of opioid administration.

NCT Number	NCT07661446
Lead Sponsor	University of Kentucky
Conditions	Opioid Use Disorders, Cannabis Use
Enrollment	100 participants
Start Date	2026-07-30
Primary Completion	2029-07-30 (estimated)
Study Completion	2030-01-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-26