Clinical Trial

Remodelling of the Lower Airways in Chronic Cough

Recruiting
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Record status
This record was last updated June 22, 2026 (before its estimated July 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
The aim of the study is to assess if chronic cough leads to injury and remodelling of the airways. We plan to analyse bronchial injury and remodelling in patients with refractory chronic cough lasting longer than 12 month . Assessment of injury mediators will be performed in blood and bronchoalveolar lavage fluid. Remodelling features will be analysed based on chest CT scan and pathologic specimens. Injury of epithelium will be assessed in bronchial biopsy specimens. The relationship between the duration, severity of chronic cough, and bronchial inflammation, damage, remodelling will be analysed.
Trial Details
NCT Number NCT07659860
Lead Sponsor Medical University of Warsaw
Conditions Chronic Cough
Enrollment 40 participants
Start Date 2022-10-01
Primary Completion 2026-07-30 (estimated)
Study Completion 2026-08-30 (estimated)
Updated on ClinicalTrials.gov 2026-06-22