Clinical Trial

QH101 Cell Injection in Patients With Brain, Brain (Spinal) Meninges, and Spinal Cord Metastatic Malignant Solid Tumors

Not Yet Recruiting Early Phase 1
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Summary
QH101 is an allogeneic TCR-enhanced Vδ2 T cell therapy product engineered to express BTN protein-specific binding elements on the cell surface. This innovative approach harnesses the natural cytotoxic capabilities of Vδ2 T cells while augmenting their ability to recognize BTN proteins, thereby significantly improving tumor cell elimination efficiency. Notably, QH101 is designed without co-stimulatory signal domains or the CD3ζ domain, which prevents T cell exhaustion from overactivation and effectively enhances in vivo persistence.
Trial Details
NCT Number NCT07656103
Lead Sponsor Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Conditions Brain Metastasis, Meningeal Metastasis, Spinal Cord Metastasis
Enrollment 7 participants
Start Date 2026-05-31
Primary Completion 2027-05-31 (estimated)
Study Completion 2027-05-31 (estimated)
Updated on ClinicalTrials.gov 2026-06-18