Clinical Trial

Caffeine and Prophylactic Noradrenaline Requirement During Cesarean Delivery

Not Yet Recruiting
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Summary
Spinal anesthesia is the preferred regional technique in obstetric practice because it provides high maternal satisfaction and eliminates the need for airway manipulation. Despite these advantages, it is frequently complicated by spinal anesthesia-induced hypotension , defined as a reduction in systolic blood pressure of more than 20% from baseline or an absolute SBP below 100 mmHg. Spinal hypotension can have serious consequences, including maternal hypoperfusion that may lead to neurological or renal dysfunction, as well as fetal acidosis and bradycardia, which can compromise neonatal outcomes. The present study aims to evaluate the effect of preoperative caffeine administration on noradrenaline requirements during spinal anesthesia in obstetric patients. Specifically, the objectives are to compare noradrenaline requirements between the study groups and to assess the incidence of hypotension in both groups.
Trial Details
NCT Number NCT07655245
Lead Sponsor Cairo University
Conditions Spinal Hypotension, Vasopressor
Enrollment 62 participants
Start Date 2026-06-16
Primary Completion 2026-09-16 (estimated)
Study Completion 2026-09-19 (estimated)
Updated on ClinicalTrials.gov 2026-06-17