Antibiotic Irrigation and Suction Ureteral Access Sheath in RIRS

Retrograde intrarenal surgery (RIRS) is a widely used treatment for kidney stones; however, postoperative infectious complications remain a significant concern. This prospective randomized factorial trial aims to evaluate whether gentamicin-containing irrigation fluid and the use of a suction ureteral access sheath can reduce postoperative fever, systemic inflammatory response syndrome (SIRS), and sepsis after RIRS. The study will also investigate the independent and combined effects of these two interventions on infectious outcomes.

NCT Number	NCT07655050
Lead Sponsor	Hitit University
Conditions	Kidney Calculi, Urolithiasis, Urinary Tract Infections
Enrollment	180 participants
Start Date	2026-06-15
Primary Completion	2027-02-08 (estimated)
Study Completion	2027-05-08 (estimated)
Updated on ClinicalTrials.gov	2026-06-24