Risk Factor Assessment for Acute Pulmonary Hypertension Crisis

The goal of this observational study is to learn about pulmonary hypertension crisis (PHC) - a severe, and often fatal complication - in patients with pulmonary hypertension (PH). The main questions this study aims to answer are: What are the clinical and hemodynamic features of PHC, and what underlying pathophysiological mechanisms cause it to develop? Can these features be used to diagnostic PHC, predict who is at risk of developing it or dying from it, and develop targeted prevention and treatment of PHC? A multi-center registry platform and biobank will be established to enroll and follow up patients with PH. Clinical data, hemodynamic measurements, and biological specimen will be collected. Risk prediction and early warning tools of PHC will be developed.

NCT Number	NCT07653958
Lead Sponsor	Peking Union Medical College Hospital
Conditions	Pulmonary Hypertension, Pulmonary Hypertension Crisis
Enrollment	5,000 participants
Start Date	2026-06-17
Primary Completion	2029-06-30 (estimated)
Study Completion	2029-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-22