Hemodynamic Effects of Norepinephrine Reduction on Critical Closing Pressure in Distributive Shock

This study prospectively observes changes in critical closing pressure (Pcc) and derived hemodynamic parameters in mechanically ventilated distributive shock patients when clinically indicated norepinephrine dose reduction is performed by the attending physician. Pcc is measured before and 30 minutes after dose reduction using a stepwise inspiratory hold maneuver via PiCCO monitoring.

NCT Number	NCT07653659
Lead Sponsor	Peking Union Medical College Hospital
Conditions	Distributive Shock, Hemodynamic Assessment, Critical Illness
Enrollment	30 participants
Start Date	2025-09-01
Primary Completion	2027-07-01 (estimated)
Study Completion	2027-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-17