Effect of Enamel Cleaning on a Remineralizing Paste for Hypomineralizated Lesions

Molar-incisor hypomineralization (MIH) is a qualitative defect of dental enamel, in which low mineral content and high protein content compromise the effectiveness of remineralizing treatments. Various agents have been used to remove proteins from hypomineralized enamel, such as sodium hypochlorite (NaOCl). Sodium hypochlorite is an antimicrobial irrigant capable of dissolving tissues. The amorphous calcium fluoride casein phosphate phosphopeptide (CPP-ACPF) is used as a remineralizing agent for MIH lesions, it is capable of stabilizing calcium, phosphate, and fluoride ions on the tooth surface, maintaining them in an amorphous form. Therefore, the objective of this study is to evaluate the clinical performance of CPP-ACPF dental mousse on deproteinized hypomineralized enamel.

NCT Number	NCT07653373
Lead Sponsor	Universidade Ceuma Collaborators: Fundação de Amparo à Pesquisa e Desenvolvimento Científico do Maranhão
Conditions	Molar Incisor Hypomineralization
Enrollment	54 participants
Start Date	2026-08
Primary Completion	2027-12 (estimated)
Study Completion	2028-04 (estimated)
Updated on ClinicalTrials.gov	2026-07-08