Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma

The goal of this observational cohort study is to learn how toxin and occupational exposures, germline genetic variation, and immune dysregulation relate to B-cell non-Hodgkin lymphoma among active-duty service members and other Military Health System beneficiaries. The main questions are whether specific exposures and germline variants are associated with B-cell NHL subtype, immune dysfunction, and clinical outcomes. Participants will complete exposure and medical-history surveys, provide biospecimens for immune and genomic testing, and may be followed annually for up to 3 years.

NCT Number	NCT07652580
Lead Sponsor	Henry M. Jackson Foundation for the Advancement of Military Medicine Collaborators: Uniformed Services University of the Health Sciences, Murtha Cancer Center, Walter Reed National Military Medical Center, United States Naval Medical Center, Portsmouth, Children's Hospital Medical Center, Cincinnati, The American Genome Center
Conditions	Non-Hodgkin Lymphoma, Lymphoma Non-Hodgkin, B-cell Lymphoma, Immune Dysregulation
Enrollment	300 participants
Start Date	2025-05-01
Primary Completion	2028-05-01 (estimated)
Study Completion	2028-05-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-17