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Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma

Study acronym: TOXNHL
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

  1. Minor Re-verified, no change to tracked fieldsv2
  2. Minor Study First Submitted
The goal of this observational cohort study is to learn how toxin and occupational exposures, germline genetic variation, and immune dysregulation relate to B-cell non-Hodgkin lymphoma among active-duty service members and other Military Health System beneficiaries. The main questions are whether specific exposures and germline variants are associated with B-cell NHL subtype, immune dysfunction, and clinical outcomes. Participants will complete exposure and medical-history surveys, provide biospecimens for immune and genomic testing, and may be followed annually for up to 3 years.
Trial Details
NCT Number NCT07652580
Lead Sponsor Henry M. Jackson Foundation for the Advancement of Military Medicine
Collaborators: Uniformed Services University of the Health Sciences, Murtha Cancer Center, Walter Reed National Military Medical Center, United States Naval Medical Center, Portsmouth, Children's Hospital Medical Center, Cincinnati, The American Genome Center
Conditions
(from sponsor)
Non-Hodgkin Lymphoma, Lymphoma Non-Hodgkin, B-cell Lymphoma, Immune Dysregulation
Related terms Immunologic Deficiency Syndromes, Lymphoma, Lymphoma, B-Cell, Lymphoma, Non-Hodgkin
Enrollment 300 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov