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Bone Defects Reconstruction After Dentigerous Cyst Enucleation With Autogenous Demineralized Dentin Matrix- ADDM and Advanced Platelet-Rich Fibrin- A-PRF.

Study acronym: Cystregen
StatusActive, Not Recruiting
PhaseNot applicable
Started
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Record History

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  1. Primary endpoint(s) modifiedv2 Show 4 more changesShow less
    • Interventions: Impacted third molar extraction with associated dentigerous cyst enucleation- blood clot healing (Procedure), Impacted third molar… to Advanced Platelet-Rich Fibrin (A-PRF) (Biological), Autogenous Demineralized Dentin Matrix (ADDM) (Biological), Impacted third molar…
    • Secondary endpoint revised
    • Study title revised
    • Study description expanded, about 1 word
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This prospective clinical study evaluates bone healing following dentigerous cyst enucleation associated with impacted mandibular third molar extraction. The study compares spontaneous blood clot healing, Advanced Platelet-Rich fibrin (A-PRF), and A-PRF combined with Autogenous Dentin Demineralized Matrix (ADDM). Bone healing is assessed as the primary outcome, while postoperative pain intensity assessed using the Numerical Rating Scale (NRS) with graphical representation represents a secondary outcome. The study aims to determine whether the use of A-PRF or A-PRF combined with ADDM improves postoperative healing outcomes compared with spontaneous blood clot healing.
Trial Details
NCT Number NCT07652216
Lead Sponsor Jagiellonian University
Conditions
(from sponsor)		 Impact Molar, Mandible Cyst, Bone Regeneration, Platelet Rich Fibrin, Dentigerous Cyst, Dentin Matrix, Autogenous Dentin Graft, Demineralized Dentin Matrix +2 more
Related terms Dentigerous Cyst
Enrollment 35 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov