Bone Defects Reconstruction After Dentigerous Cyst Enucleation With Autogenous Demineralized Dentin Matrix- ADDM and Advanced Platelet-Rich Fibrin- A-PRF.

This prospective clinical study evaluates bone healing following dentigerous cyst enucleation associated with impacted mandibular third molar extraction. The study compares spontaneous blood clot healing, Advanced Platelet-Rich fibrin (A-PRF), and A-PRF combined with Autogenous Dentin Demineralized Matrix (ADDM). Bone healing is assessed as the primary outcome, while postoperative pain intensity assessed using the Numerical Rating Scale (NRS) with graphical representation represents a secondary outcome. The study aims to determine whether the use of A-PRF or A-PRF combined with ADDM improves postoperative healing outcomes compared with spontaneous blood clot healing.

NCT Number	NCT07652216
Lead Sponsor	Jagiellonian University
Conditions	Impact Molar, Mandible Cyst, Bone Regeneration, Platelet Rich Fibrin, Dentigerous Cyst, Dentin Matrix, Autogenous Dentin Graft, Demineralized Dentin Matrix +2 more
Enrollment	35 participants
Start Date	2024-04-04
Primary Completion	2026-12-01 (estimated)
Study Completion	2027-04-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-23