Clinical Trial

DEX-HIP Trial: Preoperative IV Dexamethasone 4 mg vs Placebo to Reduce Postoperative Delirium Burden in Adults ≥70 Undergoing Hip Fracture Surgery

Completed
View on ClinicalTrials.gov →
Summary
This single-center, prospective, randomized, double-blind, placebo-controlled trial was conducted at the Department of Orthopaedic Surgery, JPMC, Karachi. Patients aged ≥60 years with hip fractures were randomized 1:1 to receive either intravenous dexamethasone or a placebo preoperatively. The primary outcome was the incidence of POD within the first five postoperative days or until discharge, assessed via the Confusion Assessment Method. Delirium severity was quantified using the validated Memorial Delirium Assessment Scale.
Trial Details
NCT Number NCT07651150
Lead Sponsor Jinnah Postgraduate Medical Centre
Conditions Delirium - Postoperative, Hip Fracture Surgeries, Steroid
Enrollment 120 participants
Start Date 2026-01-01
Primary Completion 2026-03-30 (estimated)
Study Completion 2026-04-15 (estimated)
Updated on ClinicalTrials.gov 2026-06-16