Promoting Smoking Cessation in the Community Via "Quit to Win" Contest 2026: Engagement-Focused GenAI-based Chatbot for Real-Time Smoking Cessation Support

The goal of this trial is to learn if chatbot-based instant messaging works to help smoking cessation in general adult smokers. It will also learn about the experience, attitude, and perception of using an LLM-based chatbot. The main questions it aims to answer are: 1. Will an engagement-focused LLM-based chatbot smoking cessation intervention have a non-inferior validated abstinence rate than the control group? 2. Will an LLM-based chatbot smoking cessation intervention have a non-inferior self-reported abstinence rate, smoking reduction rate, and smoking cessation services use rate than the control group? Researchers will compare an LLM-based chatbot smoking-cessation intervention to a human-led instant messaging support group (brief advice based on AWARD and personalised active referral) to determine whether chatbot-based instant messaging support promotes smoking cessation. Participants in the intervention group will receive: 1. AWARD advice 2. Personalised active referral 3. 12 weeks of chatbot-based instant messaging support (via WhatsApp)

NCT Number	NCT07649044
Lead Sponsor	The University of Hong Kong Collaborators: Hong Kong Council on Smoking and Health
Conditions	Smoking Cessation
Enrollment	998 participants
Start Date	2026-06-27
Primary Completion	2027-10-30 (estimated)
Study Completion	2028-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-06-30